6/1/2023 0 Comments Chemistry cl lynch![]() ![]() 23 Ester linkages present both advantages and disadvantages due to their lability in biological milieus, including blood, serum, or plasma, characterized by high esterase activity. reported a series of amino-acids and a small peptide linked to homoleptic bis-NHC gold( i) conjugates through ester linkages. ![]() ![]() To date, only limited studies of the post-synthetic modification or conjugation chemistry of functionalised bis-NHC gold( i) complexes have been carried out, 23 whereas analogous studies in the context of mono-NHC gold( i) complexes are common. These complementary features facilitate the synthesis of chemical libraries that may, in turn, may permit structural– activity relationships (SARs) to be explored in a biological context. 20– 22 Heteroleptic bis-NHC systems, owing to their asymmetric nature, can be easily exploited for incorporating (1) unique imidazolium N-substituents and (2) a single discrete site of functionalization. 15– 19 While homoleptic bis-NHC gold( i) complexes are common, examples of heteroleptic bis-NHC gold( i) complexes that contain two different NHCs, are rare. Recently, NHC gold( i) complexes have attracted growing interest due to their catalytic, 1– 8 luminescent, 9– 14 and biological properties. ![]()
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